DACTARI : DAtabase for Chemical Toxicity and radiotoxicity Assessment of RadIonuclides


When you click on one of the 6 results, entitled radiotoxicity, lethal dose, carcinogenicity, ingestion factor, dose coefficients or decorporation you will have access either to a detailed graph or to a coloured table of the 30 elements.

Ability of an incorporated substance to cause harmful effects on the body because of its radioactivity. Radionuclides have been classified for radiation protection purposes, into five risk groups (Delacroix, 2002) expressed in Bq. The classification is based on IAEA Basic Safety Standard.

Lethal dose of a toxic substance or radiation is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. LD50 are expressed in mg or Bq per kg of species (animal, human), and can correspond to different type of contamination (inhalation, oral or dermal). European Commission (directive 2001/59/EC) proposed a classification into 4 categories.

Ability of any substance, radionuclide or radiation, to cause cancer. This may be due to the ability to damage the genome or to the disruption of cellular metabolic processes.
The IARC (International Agency for Research on Cancer) published the classification of possible carcinogens into 5 groups (G1, G2A, G2B, G3 and G4).

The alimentary tract transfer factor, fA is the fraction (values ranging between 0 and 1) of activity entering the alimentary tract that is absorbed to blood, taking no account of losses due to radioactive decay or endogeneous input of activity into the tract.
ICRP 100 (2006) recommend values for fA.

Dose coefficients correspond to committed equivalent doses in organ or tissue per unit intake (hT(t))  or committed effective dose per unit intake e(t), where t is the time period in years aver which the dose is integrated (i.e. 50 years for adults). The term DPUI (Sv/Bq) is also used to mean dose coefficients.

Decorporation is the removal or release from tissue or a cell of radioactive material previously incorporated (inhalation , ingestion or wound) in it.

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